R&D has professionals with proven expertise in Phytochemistry, Analytical chemistry, Molecular biology, Microbiology and Pharmacology
Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of
interest to document the molecular docking analysis data of the Glucose regulated protein 78 (GRP78) with Withaferin A from Withania
somnifera in the context of COVID-19 infection for further consideration. Thus, we document the optimal interaction features of withaferin
A, artemisinin, curcumin and andrographolide with the GRP78 receptor having low binding energies (-8.7, -7.89, -6.21 and -6.17 kcal/mol
respectively) in this report. This data is compared using their interaction features with the main protease of COVID-19 to gain additional
Patent No. US10,588,885
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Ramanaiah I, Sudeep HV, David D, Shyamprasad K. Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying. BMC Complem Altern M 2019; 19: 159. http://doi.org/10.1186/s12906-019-2576-7.
Naveen P, Lingaraju HB, Deepak M, Medhini B, Shyam Prasad K. Method development and validation for the determination of caffeine, an alkaloid from Coffee arabica by HPLC method. Phcog Res 2018; 10: 88-91.
Naveen P, Lingaraju HB, Priya KS, Shyam Prasad K. Method development and validation for the determination of costunolide from Cinnamomum tamala by HPLC method. Phcog Res 2018; 10: 422-425.
Gouthamchandra K, Sudeep HV, Venkatesh BJ, Shyamprasad K. Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells. Food Science and Human Wellness 2017; 6(3): 147-153. https://doi.org/10.1016/j.fshw.2017.06.001
Bramara BVB, Vasavi HS, Sudeep HV, Shyamprasad K. Hydroalcoholic extract from Lepidium meyenii (Black maca) root exerts wound healing activity in Streptozotocin-induced diabetic rats. Wound Medicine 2017; 19: 75-81. https://doi.org/10.1016/j.wndm.2017.10.003
Vasavi HS, Sudeep HV, Lingaraju HB, Shyamprasad K. Bioavailability-enhanced ResveramaxTM modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1. Microb Pathog 2017; 104: 64-71. doi: 10.1016/j.micpath.2017.01.015.
Sudeep HV, Gouthamchandra K, Venkatesh BJ, Shyamprasad K. Viwithan, a standardized Withania somnifera root extract induces apoptosis in murine melanoma cells. Phcog Mag 2017; 13: S801-6. doi: 10.4103/pm.pm_121_17
Naveen P, Lingaraju HB, Deepak M, Medhini B, Shyam Prasad K. Method Development and Validation for the Determination of Caffeine, an alkaloid from Coffee arabica by HPLC method. Phcog Res 2017.
Sudeep HV, Venkatakrishna K, Dipak Patel, Shyamprasad K. Biomechanism of chlorogenic acid complex mediated plasma free fatty acid metabolism in rat liver. BMC Complem Altern M 2016; 16: 274. doi: 10.1186/s12906-016-1258-y.
Bioavailability-enhanced ResveramaxTM modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa
Antimicrobial efficacy of some natural cosmeceuticals, neutraceuticals and medicinal plant extracts and ultrastructural alterations in food borne pathogens
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